Burn size determines the inflammatory and hypermetabolic response

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Burn size determines the inflammatory and hypermetabolic response

BACKGROUND Increased burn size leads to increased mortality of burned patients. Whether mortality is due to inflammation, hypermetabolism or other pathophysiologic contributing factors is not entirely determined. The purpose of the present study was to determine in a large prospective clinical trial whether different burn sizes are associated with differences in inflammation, body composition, ...

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Hypermetabolic low triiodothyronine syndrome of burn injury.

The free tetraiodothyronine index (FT4I) and free triiodothyronine index (FT3I) in burn patients represented the serum levels of free (dialyzable) T4 and free T3, respectively. FT4I and FT3I were lower with greater burn size and were lower in nonsurvivors than expected for the burn size. there was no compensatory elevation of basal or releasing hormone-stimulated thyrotrophin (TSH) concentrati...

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Insulin Effects on Glucose Tolerance, Hypermetabolic Response, 1 and Circadian-metabolic Protein Expression in a Rat Burn

Corresponding Author: 21 Charles E. Wade, PhD 22 Professor of Surgery 23 Deputy Director, Center for Translational Injury Research 24 University of Texas Health Science Center at Houston 25 6431 Fannin St., MSB 5.204 26 Houston, TX 77030 27 713-500-6818-phone 28 713-500-0685-fax 29 [email protected] 30 31 Articles in PresS. Am J Physiol Regul Integr Comp Physiol (April 23, 2014). doi:1...

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Inflammatory Response to Burn Trauma: Nicotine Attenuates Proinflammatory Cytokine Levels

OBJECTIVE The immune response to an inflammatory stimulus is balanced and orchestrated by stimulatory and inhibitory factors. After a thermal trauma, this balance is disturbed and an excessive immune reaction with increased production and release of proinflammatory cytokines results. The nicotine-stimulated anti-inflammatory reflex offsets this. The goal of this study was to verify that transde...

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The effect of oxandrolone on the endocrinologic, inflammatory, and hypermetabolic responses during the acute phase postburn.

OBJECTIVE AND SUMMARY BACKGROUND DATA Postburn long-term oxandrolone treatment improves hypermetabolism and body composition. The effects of oxandrolone on clinical outcome, body composition, endocrine system, and inflammation during the acute phase postburn in a large prospective randomized single-center trial have not been studied. METHODS Burned children (n = 235) with >40% total body surf...

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ژورنال

عنوان ژورنال: Critical Care

سال: 2007

ISSN: 1364-8535

DOI: 10.1186/cc6102